An exosome is a small (diameter between 30 and 100nm) extracellular vesicle involved in intercellular communications. Exosomes contain protein, mRNA, miRNA, and dsDNA; they can transfer this cargo from one cell to another, influencing the immune system and activating the organism’s responses to events such as wounds. They have been harnessed by tumors for potential metastatic activity and by researchers for localized tumor-specific drug delivery.
Evaluation of tumor-derived exosomal miRNA as potential diagnostic biomarkers for early stage non-small-cell lung cancer using next-generation sequencing.
Xiance Jin, Yanfan Chen, Hanbin Chen, Shaoran Fei, Didi Chen, Xiaona Cai, Linger Liu, Baochai Lin, Huafang Su, Lihao Zhao, Meng Su, Huanle Pan, Lanxiao Shen, Deyao Xie, Congying Xie.
Clinical Cancer Research, June 12 2017. DOI: 10.1158/1078-0432.CCR-17-0577 Link to Article